Clemson Canine Genetics

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Dr. Leigh Anne Clark

Dr. Leigh Anne Clark, Associate Professor

Leigh Anne and Watson, 2015


2000 B.S. - Biomedical Sciences, Texas A & M University
2004 Ph.D. - Genetics, Texas A & M University


Google Scholar Citations for this Researcher


Recent Publications

Evans JM, Noorai RE, Tsai KL, Starr-Moss AN, Hill CM, Anderson KJ, Famula TR, Clark LA (2017). Beyond the MHC: A canine of dermatomyositis shows a complex pattern of genetic risk involving novel loci. PLoS Genetics 13(3): e1006604.

Evans JM, Cox ML, Huska J, Li F, Gaitero L, Guo LT, Casal ML, Granzier HL, Shelton GD, Clark LA (2016). Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy. Mammalian Genome 27:495-502.

Rinz C.J., Lennon V.A., James F., Thoreson J., Tsai K.L., Starr-Moss A.N., Humpries H.D., Guo L.T., Palmer A.C., Clark L.A., Shelton G.D. (2015). A CHRNE frameshift mutation causes congenital myasthenic syndrome in young Jack Russell terriers. Neuromuscular Disorders 25:921-927.

Evans, J.M., K.L. Tsai, A.N. Starr-Moss, J.M. Steiner, and L.A. Clark (2015) Association of DLA-DQB1 Alleles with Exocrine Pancreatic Insufficiency in Pembroke Welsh Corgis. Animal Genetics 46:462-465.

Rinz, C.J., J. Levine, K.M. Minor, H.D. Humphries, R. Lara, A.N. Starr-Moss, L.T. Guo, G.D. Shelton, and L.A. Clark (2014) A COLQ Missense Mutation in Labrador Retrievers Having Congenital Myasthenic Syndrome. PLoS ONE 9(8): e106425. 

Clark, L.A. and A.N. Starr-Moss (2013). Genetics and Genomics of the Domestic Dog. In: Animal Molecular and Quantitative Genetics. Ed: H. Khatib. Hoboken, New Jersey. Wiley-Blackwell. (in press). 

Tsai, K.L., A.N. Starr-Moss, G.M. Venkataraman, C. Robinson, L.j. Kennedy, J.M. Steiner, and L.A. CLark (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics 65: 501-509.

Noorai, R.E., N.H. Freese, L.M. Wright, S.C. Chapman* and L.A. Clark* (2012). Genome-wide Association Mapping and Identification of Candidate Genes for Rumpless and Ear-tufted Traits of the Araucana Chicken. PLoS ONE 7(7):e40974.

Clark, L.A. and M.L. Cox (2012). Current status of genetic studies of exocrine pancreatic insufficiency in dogs. Topics in Companion Animal Medicine 10.1053/j.tcam.2012.04.001

Tsai, K.L., R.E. Noorai, A.N. Starr-Moss, P. Quignon, C.J. Rinz, E.A. Ostrander, J.M. Steiner, K.E. Murphy and L.A. Clark (2012). Genome-wide association studies for multiple diseases of the German Shepherd Dog. Mammalian Genome 23:203-211.

Gill, J.L., K.L. Tsai, C. Krey, R.E. Noorai, J.F. Vanbellinghen, L.S. Garosl, G.D. Shelton, L.A. Clark* and R.J. Harvey* (2012). A canine BCAN microdeletion associated with episodic falling syndrome. Neurobiology of Disease 45 (1):130-136.

Clark, L.A., K.L. Tsai, A.N. Starr, K.L. Nowend and K.E. Murphy (2011). A missense mutation in the 20S proteasome B2 subunit of Great Danes having harlequin coat patterning. Genomics 97: 244-248.

Spadafora, D., E.C. Hawkins, K.E. Murphy, L.A. Clark and S. T. Ballard (2010). Naturally-occurring mutations in the canine CFTR gene. Physiological Genomics 42: 480-485.

Strain, G, L.A. Clark, J.M. Wahl, A. Turner and K.E. Murphy (2009). Prevalence of deafness in dogs heterozygous or homozygous for the merle allele. Journal of Veterinary Internal Medicine 23: 282-286.

Clark, L.A., J.M. Wahl, C.A. Rees, G.M. Strain, E.J. Cargill, S.L. Vanderlip and K.E. Murphy (2008). Canine SINEs and their effects on phenotypes of the domestic dog. In: Genomics of Disease. Eds: J.P.Gustafson, J. Taylor, G. Stacey. New York, New York. Springer Science+Business Media, LLC: 79-88.

Wahl, J.M., S. Herbst, L.A. Clark, K.L. Tsai and K.E. Murphy (2008). A review of hereditary diseases of the German Shepherd Dog. Journal of Veterinary Behavior 3 (6): 255-65.

Clark, L.A., A.N. Starr, K.L. Tsai and K.E. Murphy (2008). Genome-wide linkage scan localizes the harlequin locus in the Great Dane to chromosome 9. Gene 418 (1-2): 49-52.

Clark, L.A., K.L. Tsai and K.E. Murphy (2008). Alleles of DLA-DRB1 are not unique in German Shepherd Dogs having degenerative myelopathy. Animal Genetics 39 (3): 332.

Wahl, J.M., L.A. Clark, O. Skalli, A. Ambrus, C.A. Rees, J.L. Mansell and K.E. Murphy (2008). Analysis of gene transcript profiling and immunobiology in Shetland sheepdogs with dermatomyositis. Veterinary Dermatology 19 (2): 52-58.

Kerns, J., E.J. Cargill, L.A. Clark, S. Candille, T. Berryere, M. Olivier, G. Lust, S. Schmutz, K. Murphy and G. Barsh (2007). Linkage and segregation analyses of black and brindle coat color in domestic dogs. Genetics 176 (3): 1679-1689.

Tsai K.L., L.A. Clark and K.E. Murphy (2007). Understanding hereditary diseases using the dog and human as companion model systems. Mammalian Genome 18 (6-7): 444-451.

Clark, L.A., J.M. Wahl, C.A. Rees and K.E. Murphy (2006). Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog. Proceedings of the National Academy of Sciences 103: 1376-1381. (work highlighted by: a. accompanying Commentary; b. mention in This Week in PNAS and; c. selection of an image for the cover).



Leigh Anne with a Mackenzie River Husky at Denali, AK (2007)                                            Leigh Anne with her husband, Dion, at the Anderson Motor Speedway (2012)

Leigh Anne and Hobbes (2012)
                                            Leigh Anne's daughter Ryleigh, with her friend Dusty (2015)


Leigh Anne's daughter Regan (2015)                                                            Leigh Anne and Chase (2011)