Clemson Canine Genetics

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Dr. Leigh Anne Clark

Dr. Leigh Anne Clark, Associate Professor

2000 B.S. - Biomedical Sciences, Texas A & M University

2004 Ph.D. - Genetics, Texas A & M University 


Google Scholar Citations for this Researcher


Recent Publications

Bell SM, Evans JM, Evans KM, Tsai KL, Noorai RE, Famula TR, Holle DM, Clark LA (2022). Congenital idiopathic megaesophagus in the German shepherd dog is a sex-differentiated trait and is associated with an intronic variable number tandem repeat in Melanin-Concentrating Hormone Receptor 2. PLOS Genetics 18(3):e1010044.

Abrams SR, Hawks AL, Evans JM, Famula TR, Mahaffey M, Johnson GS, Mason JM, Clark LA (2020). Variants in FtsJ RNA 2´-O-Methyltransferase 3 and Growth Hormone 1 are associated with small body size and a dental anomaly in dogs. Proceedings of the National Academy of Sciences 117(40): 24929-24935.

Tsai KL, Vernau KM, Winger K, Zwueste DM, Sturges BK, Knipe M, Williams DC, Anderson KJ, Evans JM, Guo LT, Clark LA, Shelton GD (2019). Congenital myasthenic syndrome in Golden Retrievers is associated with a novel COLQ mutation. Journal of Veterinary Internal Medicine 34(1), 258-265.

Tsai KL, Evans JM, Noorai RE, Starr-Moss AN, Clark LA (2019). Novel Y Chromosome Retrocopies in Canids Revealed through a Genome-Wide Association Study for Sex. Genes 10(4): 320.

Murphy SC, Recio A, de la Fuente C, Guo LT, Shelton GD, Clark LA (2019). A glycine transporter SLC6A5 frameshift mutation causes startle disease in Spanish greyhounds. Human Genetics 1-5.

Murphy SC, Evans JM, Tsai KL, Clark LA (2018). Length variations within the Merle retrotransposon of canine PMEL: correlating genotype with phenotype. Mobile DNA 9:26.

Cox ML, Evans JM, Davis AG, Guo LT, Levy JR, Starr-Moss AN, Salmela E, Hytonen MK, Lohi H, Campell KP, Clark LA, Shelton GD (2017). Exome sequencing reveals independent SGCD deletions causing limb girdle muscular dystrophy in Boston terriers. Skeletal Muscle 7:15.

Evans JM, Noorai RE, Tsai KL, Starr-Moss AN, Hill CM, Anderson KJ, Famula TR, Clark LA (2017). Beyond the MHC: A canine of dermatomyositis shows a complex pattern of genetic risk involving novel loci. PLoS Genetics 13(3): e1006604.

Evans JM, Cox ML, Huska J, Li F, Gaitero L, Guo LT, Casal ML, Granzier HL, Shelton GD, Clark LA (2016). Exome sequencing reveals a nebulin nonsense mutation in a dog model of nemaline myopathy. Mammalian Genome 27:495-502.

Rinz C.J., Lennon V.A., James F., Thoreson J., Tsai K.L., Starr-Moss A.N., Humpries H.D., Guo L.T., Palmer A.C., Clark L.A., Shelton G.D. (2015). A CHRNE frameshift mutation causes congenital myasthenic syndrome in young Jack Russell terriers. Neuromuscular Disorders 25:921-927.

Evans, J.M., K.L. Tsai, A.N. Starr-Moss, J.M. Steiner, and L.A. Clark (2015) Association of DLA-DQB1 Alleles with Exocrine Pancreatic Insufficiency in Pembroke Welsh Corgis. Animal Genetics 46:462-465.

Rinz, C.J., J. Levine, K.M. Minor, H.D. Humphries, R. Lara, A.N. Starr-Moss, L.T. Guo, G.D. Shelton, and L.A. Clark (2014) A COLQ Missense Mutation in Labrador Retrievers Having Congenital Myasthenic Syndrome. PLoS ONE 9(8): e106425. 

Clark, L.A. and A.N. Starr-Moss (2013). Genetics and Genomics of the Domestic Dog. In: Animal Molecular and Quantitative Genetics. Ed: H. Khatib. Hoboken, New Jersey. Wiley-Blackwell. (in press). 

Tsai, K.L., A.N. Starr-Moss, G.M. Venkataraman, C. Robinson, L.j. Kennedy, J.M. Steiner, and L.A. CLark (2013). Alleles of the major histocompatibility complex play a role in the pathogenesis of pancreatic acinar atrophy in dogs. Immunogenetics 65: 501-509.

Noorai, R.E., N.H. Freese, L.M. Wright, S.C. Chapman* and L.A. Clark* (2012). Genome-wide Association Mapping and Identification of Candidate Genes for Rumpless and Ear-tufted Traits of the Araucana Chicken. PLoS ONE 7(7):e40974.

Clark, L.A. and M.L. Cox (2012). Current status of genetic studies of exocrine pancreatic insufficiency in dogs. Topics in Companion Animal Medicine 10.1053/j.tcam.2012.04.001

Tsai, K.L., R.E. Noorai, A.N. Starr-Moss, P. Quignon, C.J. Rinz, E.A. Ostrander, J.M. Steiner, K.E. Murphy and L.A. Clark (2012). Genome-wide association studies for multiple diseases of the German Shepherd Dog. Mammalian Genome 23:203-211.

Gill, J.L., K.L. Tsai, C. Krey, R.E. Noorai, J.F. Vanbellinghen, L.S. Garosl, G.D. Shelton, L.A. Clark* and R.J. Harvey* (2012). A canine BCAN microdeletion associated with episodic falling syndrome. Neurobiology of Disease 45 (1):130-136.

Clark, L.A., K.L. Tsai, A.N. Starr, K.L. Nowend and K.E. Murphy (2011). A missense mutation in the 20S proteasome B2 subunit of Great Danes having harlequin coat patterning. Genomics 97: 244-248.

Spadafora, D., E.C. Hawkins, K.E. Murphy, L.A. Clark and S. T. Ballard (2010). Naturally-occurring mutations in the canine CFTR gene. Physiological Genomics 42: 480-485.

Strain, G, L.A. Clark, J.M. Wahl, A. Turner and K.E. Murphy (2009). Prevalence of deafness in dogs heterozygous or homozygous for the merle allele. Journal of Veterinary Internal Medicine 23: 282-286.

Clark, L.A., J.M. Wahl, C.A. Rees, G.M. Strain, E.J. Cargill, S.L. Vanderlip and K.E. Murphy (2008). Canine SINEs and their effects on phenotypes of the domestic dog. In: Genomics of Disease. Eds: J.P.Gustafson, J. Taylor, G. Stacey. New York, New York. Springer Science+Business Media, LLC: 79-88.

Wahl, J.M., S. Herbst, L.A. Clark, K.L. Tsai and K.E. Murphy (2008). A review of hereditary diseases of the German Shepherd Dog. Journal of Veterinary Behavior 3 (6): 255-65.

Clark, L.A., A.N. Starr, K.L. Tsai and K.E. Murphy (2008). Genome-wide linkage scan localizes the harlequin locus in the Great Dane to chromosome 9. Gene 418 (1-2): 49-52.

Clark, L.A., K.L. Tsai and K.E. Murphy (2008). Alleles of DLA-DRB1 are not unique in German Shepherd Dogs having degenerative myelopathy. Animal Genetics 39 (3): 332.

Wahl, J.M., L.A. Clark, O. Skalli, A. Ambrus, C.A. Rees, J.L. Mansell and K.E. Murphy (2008). Analysis of gene transcript profiling and immunobiology in Shetland sheepdogs with dermatomyositis. Veterinary Dermatology 19 (2): 52-58.

Kerns, J., E.J. Cargill, L.A. Clark, S. Candille, T. Berryere, M. Olivier, G. Lust, S. Schmutz, K. Murphy and G. Barsh (2007). Linkage and segregation analyses of black and brindle coat color in domestic dogs. Genetics 176 (3): 1679-1689.

Tsai K.L., L.A. Clark and K.E. Murphy (2007). Understanding hereditary diseases using the dog and human as companion model systems. Mammalian Genome 18 (6-7): 444-451.

Clark, L.A., J.M. Wahl, C.A. Rees and K.E. Murphy (2006). Retrotransposon insertion in SILV is responsible for merle patterning of the domestic dog. Proceedings of the National Academy of Sciences 103: 1376-1381. (work highlighted by: a. accompanying Commentary; b. mention in This Week in PNAS and; c. selection of an image for the cover).



Leigh Anne with a Mackenzie River Husky at Denali, AK (2007)                                           

Leigh Anne and Hobbes (2012)

Leigh Anne and Chase (2011)

Leigh Anne and Watson (2015)